Tag Archives: stomach cancer

Prophylactic Total Gastrectomy to Manage Hereditary Gastric Cancer Risk

Roux-Y reconstruction with esophagojejunostomy. ©Steinemann et. al.; licensee BioMed Central Ltd. 2011.

Roux-Y reconstruction with esophagojejunostomy. ©Steinemann et. al.; licensee BioMed Central Ltd. 2011.

Minimally invasive surgical treatment options are helping to revolutionize surgical care for patients with many upper gastrointestinal cancers and pre-cancerous syndromes at Penn State Health.  Hereditary Diffuse Gastric Cancer (HDGC) is an inherited, autosomal dominant syndrome with high (80%) penetrance which results in invasive stomach cancers (often multifocal) at a relatively young age (30-50 years old)1.  Mutations in the E-cadherin (CDH1) are usually the cause of HDGC and patients often have a strong family history of stomach cancer and breast cancer (lobular breast cancer is also associated with CDH1 mutations)2. Continue reading

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