Tag Archives: pancreas

Innovative and Minimally Invasive Techniques for Pancreatic Cyst Ablation and Cancer Prevention

Cancer of the pancreas remains one of the greatest clinical challenges in oncology. With no reliable screening tests and a poor prognosis following identification, the need for novel approaches toward this disease remains largely unmet.

In recent years, however, pre-malignant pancreatic cystic lesions have been increasingly discovered in patients undergoing cross-sectional imaging for unrelated reasons. While over half of pancreatic cystic lesions have little to no malignant potential, mucinous cystic neoplasms (MCNs) and intraductal papillary mucinous neoplasms (IPMNs) can carry a high potential for progression into pancreatic cancer.

Discovering a pancreatic cyst poses a new set of difficulties. According to Matthew T. Moyer, M.D. M.S., associate professor of medicine, Penn State Hershey Medical Center, “Either serial radiographic surveillance or surgical resection is generally recommended for these cysts, both of which have significant limitations. Surveillance is inconvenient and expensive with no therapeutic aspect, while surgical resection is associated with a significant risk of morbidity (20 to 40 percent) and mortality (1 to 2 percent).” Continue reading

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Minimally Invasive and Maximally Effective Approaches to Pancreatic Fluid Collections and Pancreatic Necrosis

Severe necrotizing pancreatitis represents an enormous clinical problem due to its prevalence, economic costs and high levels of morbidity and mortality. After an initial period characterized by systemic inflammatory response, the leading cause of mortality stems from infection of the pancreatic necrosis which develops in 40-70 percent of patients. 1 Without intervention, the mortality rate of this group is exceedingly high, but can be significantly reduced using various methods of surgical pancreatic necrosectomy. However, with perioperative mortality rates of 10-40 percent and complication rates in excess of 70 percent, conventional pancreatic necrosectomy presents its own problems and is typically approached with trepidation. Additionally, repeated trips to the operating room are often required. 2,3    Continue reading

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