Severe necrotizing pancreatitis represents an enormous clinical problem due to its prevalence, economic costs and high levels of morbidity and mortality. After an initial period characterized by systemic inflammatory response, the leading cause of mortality stems from infection of the pancreatic necrosis which develops in 40-70 percent of patients. 1 Without intervention, the mortality rate of this group is exceedingly high, but can be significantly reduced using various methods of surgical pancreatic necrosectomy. However, with perioperative mortality rates of 10-40 percent and complication rates in excess of 70 percent, conventional pancreatic necrosectomy presents its own problems and is typically approached with trepidation. Additionally, repeated trips to the operating room are often required. 2,3 Continue reading
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